การเตรียมสารสังเคราะห์ไตรเอโซลไกลโคไซด์เพื่อศึกษาสมบัติการต้านมะเร็งท่อน้ำดี

Abstract

A new series of 1,6-bis-triazole 2,3,4-tri-O-acetyl-D-galactopyranosy1 derivatives were synthesized and evaluated for their in vitro cytotoxic activities against Thai human cholangiocarcinoma cells (KKU-M213, HUCCA-1, K-100). Thirty-two examples were prepared in high yields (70-99%) and the preliminary screening results indicated that some of the compounds demonstrated low to moderate cytotoxic activities. Compounds 12 ee exhibited pronounced cytotoxicity against K-100 cell lines, comparable to the anticancer drug ellipticin. The chemical structures of all the newly synthesized compounds were characterized by means of spectral and elemental analyses.